Bicarbonate & Acid Powder

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Powder or Dry Bicarbonate concentrate for 5008 4008 S NG machine

Chronic metabolic acidosis is common in dialysis patients. Bicarbonate administration via the dialysate helps maintain the acid-base balance in these patients.

In bicarbonate dialysis, proportioning pumps in the dialysis machine mix purified water with separate “acid” and bicarbonate concentrates. The “acid” concentrate contains electrolytes, glucose, and 2–8 mEq/L of acetate (which is metabolized into bicarbonate in the liver) to prevent calcium precipitation.

One of the functions of the human kidney is to regenerate bicarbonate. Haemodialysis (HD) replaces this function by including the supraphysiological concentration of base in the dialysis fluid. In the early days the natural buffer, bicarbonate, was the obvious choice but there were technical problems with its preparation and delivery. In the mid-60s the introduction of acetate, which is metabolized to bicarbonate, solved many of these problems.

The disadvantage of acetate became apparent a decade later when the improvement in the efficiency of HD revealed the potential for overwhelming the capacity of some patients to metabolize acetate.

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